550 bacterial species
120 index bacteria
23 resistance genes
PadoBiom® analyzes the subgingival microbiome using a patented Next-Generation Sequencing (NGS) method, screening over 7,000 taxonomic classifications — including bacteria, fungi, viruses, and parasites — and approximately 550 oral bacterial species to calculate a Dysbiosis Index based on around 120 periodontitis- and health-associated bacteria.
The evaluated parameters also include 23 relevant antibiotic resistance genes across 6 antibiotic classes. In this process, the Dysbiosis Index assesses the balance between periodontitis- and health-associated bacteria. In addition, an algorithm calculates the dysbiosis progression risk, providing objective microbiological baseline data to assist clinicians in their overall patient evaluation.
The ratio of health-associated to periodontitis-associated bacteria reflects the microbial balance within the periodontal pocket. The dysbiosis index makes shifts in the subgingival microbiome visible at the laboratory level—even before marked clinical symptoms appear.
Dysbiosis in the microbiome
Antibiotic resistance
Progression risk of dysbiosis
Health-associated / Periodontitis-associated / Core species / Other species
Analysis of over 550 bacterial species
Main contributing bacteria with a proportion > 0.1%
Detection of pathogenic & highly pathogenic marker bacteria + Aa serotypes
The detection of resistance genes indicates an increased risk of diminished or absent efficacy for the affected antibiotics. Because genetic markers do not necessarily result in phenotypic expression, the laboratory report serves as an informative decision-making aid for dental treatment planning.
Use PadoBiom® as an objective decision-making aid to identify microbial dysbiosis at an early stage and precisely profile individual risks and relevant resistance genes in active periodontitis: