PadoGen

Analysis of genetically-related susceptibility to inflammation

Periodontitis is an infectious disease of the periodontium caused by certain bacteria. However, the extent and progress of the disease are largely determined by the response of the immune system to the subgingival microbiome that is present. The level of hereditary inflammatory propensity depends on the number of polymorphisms and the ratio of pro- and anti-inflammatory cytokines which are present. In particular, alterations in the genes of the cytokines interleukin-1α, interleukin-1β, the interleukin-1 receptor antagonist (IL-1-RN) and tumor necrosis factor-α result in a shifted ratio of pro- and anti-inflammatory cytokines.

Patients with a higher genetic tendency to inflammation have an increased risk of periodontal disease. In addition, they are affected by more severe clinical courses than average. At the same time, they show significantly reduced acceptance of dental treatment and significantly more frequent implant complications or losses.

Order PadoGen?

From now on, PadoGen can be ordered via an order form that is additionally enclosed. You can also order this form conveniently via our store.

The application of the PadoGen has the purpose of: 

• differential diagnosis in case of above-average disease progression despite inconspicuous microbiological findings.
• validation of future disease progression (grading).
• estimation of the course of therapy and treatment planning for periodontitis and periimplantitis.
• risk analysis before implantations (especially for smokers: higher legal certainty and increase of patient compliance).
• clarification of familiar predisposition.
• motivation of the patient to achieve optimal oral hygiene and compliance and to avoid risk factors.

In combination with the extent of a patient's subgingival bacterial exposure by the PadoTest^® as well as any other risk factors, knowledge of the PadoGen grade enables more informed treatment planning:

• antimicrobial and, if necessary, anti-inflammatory therapy
• tighter recall program
• motivation for optimal oral hygiene and compliance
• avoidance of exogenous risk factors (e.g. smoking, stress, poor oral hygiene)

You still have sampling sets with the previous order form? No problem!
You can also use your existing sampling sets for PadoGen, even if there is no selection option for PadoGen on your order form yet. To do so, fill in the order/test number of the existing sampling set in the column provided on the form and manually leave a note with "PadoGen" above the column. In addition, download the new order form here and return it to us fully completed. Alternatively, you can request it by phone (Free Hotline: 00800 32 32 62 62) or by mail (Contact - PadoTest^®). Please send us both the current, filled-out form and the present, previous form (unfilled).

If you want to order PadoGen subsequently to an already performed analysis, download the order form or request a current form and enter the T-number of the previously performed analysis. In addition, leave a note by hand with "Follow-up order".

Please note:
For PadoGen we always require the completed and signed "Declaration of consent for a molecular genetic analysis pursuant to the german genetic diagnostics act". This can be found on the second page (on the back side) of the order form.